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极低出生体质量儿氨茶碱药代动力学研究
Investigation on Pharmacokinetics of Aminophylline in Very Low Birth Weight Infants
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摘要:
【摘要】 目的探讨氨茶碱在不同孕周、不同体质量及不同日龄极低出生体质量儿体内的药代动力学特点。方法采用单中心、开放式研究方法。纳入标准为2011～2012年在我院新生儿科住院新生儿,孕周<34周,出生体质量<1500g,临床有呼吸暂停症状。所有患儿均接受负荷剂量为5mg/kg氨茶碱静脉治疗,在给予首次负荷剂量后8h、5d给药前半小时采血检测氨茶碱血药浓度及肝肾功能,停止治疗前每周定期复查氨茶碱血药浓度(与上次采血时间间隔7d)。采用MW/Pharm3.6软件计算药代动力学参数,建立群体药代动力学模型;同时进行相关性统计分析。结果共纳入患儿104例,平均出生体质量为(1.15?0.23)kg,孕周为(31.19?2.50)周。氨茶碱血浆清除率为(17.88?5.61)mL/(kg.h),表观分布容积为(0.93?0.18)L/kg,半衰期为(28.6?7.59)h。氨茶碱血浆清除率与内生肌酐清除率、孕龄及出生后日龄相关(相关系数r分别为0.68、0.62和0.56,P均<0.05),表观分布容积与出生体质量相关(相关系数r为0.82,P<0.05)。建立的群体药代动力学模型能够很好的预测患儿血药浓度-时间曲线。结论极低出生体质量儿氨茶碱药代动力学参数与成年人比较具有较大差异,临床治疗及对氨茶碱进行剂量调整时应考虑患儿孕龄及生后日龄,进行常规血药浓度监测。
Abstract:【Abstract】
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Keywords:
- Pharmacokinetics /
- Aminophylline /
- Very low birth weight infant
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