Abstract: 【Abstract】 Lung cancer is the leading cause of cancer-related death worldwide. The topics of this issue include the changes of lung cancer epidemiology and its histological characteristics, the value of low dose CT in early detection of lung cancer and the image characteristics of solitary pulmonary nodule in early diagnosis of lung cancer, the advances in the therapeutic strategies for lung cancer with brain metastases and pulmonary sarcomatoid carcinoma, and new potential targets of molecular targeted therapy in lung cancer. In order to more effectively improve the survival and prognosis of the patients with lung cancer, it is necessary to strengthen basic research on the molecular pathogenesis of lung cancer, and to translate the advances in basic research into the efforts of exploring the specific and sensitive diagnosis tools for lung cancer, and so increasing the accuracy of early screening and diagnosis, as well as classifying the lung cancer by molecular pathology to achieve individualized therapy.