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白细胞介素1A基因3′-UTR插入/缺失多态与中国汉族前列腺癌的相关性研究

Insertion/Deletion Polymorphism of IL1A 3′-UTR Associated with the Susceptibility of Prostate Cancer

  • 摘要: 目的 研究白细胞介素1A基因(IL1A)3′-UTR区"TTCA"插入(I)/缺失(D)多态性位点与中国汉族男性前列腺癌之间的关系。方法 采用聚合酶链反应-聚丙烯酰胺凝胶电泳(PCR-PAGE)方法,在131例前列腺癌患者和229例正常对照者样本中对IL1A基因3′-UTR区"TTCA"插入/缺失多态性位点(rs3783553)进行基因分型,分析比较两组样本间等位基因频率及基因型频率分布差异,探讨该位点与前列腺癌的相关性。结果 基因分型结果显示,两组样本中rs3783553位点基因型频率分布均符合Hardy-Weinberg平衡;统计结果显示,与D/D基因型相比,基因型为 D/I 或 I/I的个体罹患前列腺癌的风险降低(P=0.48,95%CI:0.31~0.74);相对于等位基因D,等位基因I罹患前列腺的风险降低(P=0.001,OR=0.56,95%CI:0.40~0.79)。结论 IL1A基因3′-UTR区"TTCA"四碱基插入/缺失多态性可能与中国汉族男性前列腺癌的发病相关。

     

    Abstract: Objective To identify the association between the insertion/deletion polymorphism of interleukin-1A gene (IL1A) and the susceptibility of prostate cancer (PCA). Methods We performed a case-control study enrolling 131 PCA patients and 229 healthy control subjects in a Chinese Han population. The TTCA insertion/deletion polymorphism (rs3783553) in 3′-UTR of IL1A gene was genotyped by PCR-RFLP method. Results The genotype distribution of rs3783553 in both groups met the requirements of Hardy-Weinberg equilibrium. Significantly reduced PCA risk was associated with D/I and I/I genotype compared to D/D genotype (POR=0.48, 95%CI: 0.31-0.74), and allele I is associated with the reduced PCA risk (P=0.001,OR=0.56,95%CI: 0.40-0.79). Conclusion TTCA insertion allele of rs3783553 contributes to the reduction of the susceptibility to prostate cancer.

     

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