慢性阻塞性肺疾病与肺癌发生的关系研究

Association of Chronic Obstructive Pulmonary Disease and Lung cancer

摘要: 目的探讨慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）与肺癌的临床相关性。方法收集肺癌患者180例、非肺癌对照组200例的临床资料〔包括病史、临床检查及1 s用力呼气容积（FEV1）〕，比较分析肺癌发生的相关危险因素。结果有慢性支气管炎、肺气肿、COPD或肺结核病家族史的患者，肺癌发生的风险增高（P<0.05)。现患COPD者比无COPD者发生肺癌的风险高2.78倍 (OR=2.78)；当FEV1<80%时，肺癌发生的风险增高（P<0.05)。排除吸烟这一混杂因素后，现患COPD、低FEV1仍与肺癌发生有关。结论现患COPD及有COPD家族史均与肺癌发生有关。

Abstract: Objective To investigate the association between chronic obstructive pulmonary disease (COPD) and lung cancer. Methods A case-control study was undertaken, with 180 cases of lung cancer and 200 cases of controls. Results The odd of lung cancer was higher in patients with COPD, emphysema, chronic bronchitis, and pulmonary tuberculosis （P<0.05). The odd of lung cancer increased significantly in patients with a family history of lung cancer or COPD （P<0.05). The odd of lung cancer also increased when forced expiratory volume in one second （FEV1）<80%. Conclusion Patients with COPD or a family history of COPD have higher risk of lung cancer.