系统性红斑狼疮患者血清Hcy水平及其与临床指标的相关性研究

丁小洁; 陈燕; 段茜; 王理; 刘影

系统性红斑狼疮患者血清Hcy水平及其与临床指标的相关性研究

The Correlation Between Serum Hcy Level and Clinical Indicators in Systemic Lupus Erythematosus Patients

摘要

摘要:
目的探讨系统性红斑狼疮(systemic lupus erythematosus，SLE)患者血清同型半胱氨酸(homocysteine，Hcy)水平及其相关影响因素分析。
方法 90例SLE患者作为研究对象，根据狼疮疾病活动指数(systemic lupus erythematosus disease activity index，SLEDAI)评分分为活动期(＞9分)41例，非活动期(≤9分)49例，选择同期体检健康者46例为对照，分别检测血清总胆固醇(total cholesterol，TC)、三酰甘油(triacylglyceride，TG)、血肌酐(Ser)、C反应蛋白(C-reactive protein，CRP)、血清胱抑素(cystatin c，CysC)和Hcy水平，分析Hcy与SLE患者SLEDAI评分及其它血清指标的关系。
结果 SLE患者体内Hcy、TG、TC、CRP、CysC等水平均高于健康对照组(P＜0.05)，而活动期SLE患者血清Hcy水平高于非活动期SLE患者，差异有统计学意义(P＜0.05)，SLE活动期、非活动期及健康对照的Ser水平差异无统计学意义(P＞0.05)；SLE患者血清Hcy水平和SLEDAI评分、CysC水平呈正相关(相关系数r=0.698 3和0.597 5，P＜0.01)，和CRP、TC、TG、Ser水平之间无明显相关性(P＞0.05)。
结论 SLE患者血清Hcy水平高于正常人，Hcy水平和SLE患者病情程度有关，可将Hcy水平和SLEDAI评分作为评价SLE病情活动度的指标。

Abstract:
Objective To explore the serum homocysteine (Hcy) level and its influence factors in systemic lupus erythematosus (SLE) patients.
Methods 90 SLE patients were included in the study. According to the systemic lupus erythematosus disease activity index (SLEDAI) score, 41 patients were in active stage (> 9 scores), 49 patients were in inactive stage (≤9 scores), while 46 healthy individuals were selected as controls. Total cholesterol (TC), triacylglyceride (TG), serum creatinine (Ser), C-reactive protein (CRP), serum cystatin (cystin c, CysC) and Hcy level were measured. Analysis on the relationship between Hcy level and SLEDAI score, as well as serum indicators was conducted.
Results The levels of Hcy, TG, TC, CRP and CysC in SLE patients were higher than healthy controls (P < 0.05), and the serum level in active SLE patients was higher than inactive SLE patients (P < 0.05). There was no significant difference in Ser level among the active SLE patients, inactive SLE patients and healthy controls (P>0.05). There was a positive correlation between Hcy level and SLEDAI score (r=0.698 3, P < 0.01), as well as CysC (r=0.597 5, P < 0.01). There was no significant correlation between Hcy level and CRP, TC, TG and Ser levels (P>0.05).
Conclusion The Hcy level in SLE patients was higher than healthy controls. The level of Hcy was positively correlated with the degree of disease activity. The Hcy level and SLEDAI score can be used as indicators to evaluate the activity of SLE.

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