Abstract: Objective To detect the expression of Pokemon in endometrial carcinoma(EC), to provide preliminary theoretical basis for clarifying pathogenesis and searching for effective targets. Methods Ninety-eight cases of endometrial tissue paraffin specimens form July 2012 to July 2014 in West China Second University Hospital, Sichuan University, were collected, including: EC group, consisting of adenocarcinoma 23 cases, adenosquamous 12 cases, serous 3 cases, mucinous 11 cases and clear cell 9 cases, and control group, consisting of atypical hyperplasia endometrium 20 cases and normal endometrium 20 cases (secretory 10 cases, hyperplasia 10 cases). Immunohistochemistrywas used to detect the expression of Pokemonin each section, analyzing the correlation of Pokemon expression with clinicopathologic characteristics and p53 expression. Results The positive rate of Pokemon in normal endometrium was 25% (5/20), significantly lower than that in atypical hyperplasia endometrium (60.0%, 12/20) and EC (93.1%, 54/58) (P<0.05); the rate in type Ⅱ was 97.12% (34/35), significantly higher than that in type Ⅰ (86.96%, 20/23) (P=0.018). The positive rate of Pokemon in Ⅲ-Ⅳ stage, type Ⅱ and Ki-67≥50 EC tissue was much higher (P=0.012, 0.023, 0.029). In type Ⅱ EC tissue, the correlation index between Pokemon and p53 is 0.669 (P=0.000). Conclusion The over expression of Pokemon upregulates the expression of mutant p53, which may be one of the carcinogenesis modes in type Ⅱ EC.