Abstract: ObjectiveTo study the expression and clinical significance of phosphoinositide-specific phospholipase Cε1 (PI-PLCε1) in the pathogenesis of colon cancer. MethodsqRT-PCR and immunohistochemistry were used to detect the expression of PI-PLCε1in the 42 cases of colon cancer tissues and their corresponding adjacent tissues. And the effects of tumor differentiation and tumor site on the expression PI-PLCε1 of colon cancer tissues were compared. ResultsThe results of qRT-PCR showed that the expression of PI-PLCε1in colon cancer tissue significantly lower than that in the adjacent tissue ( P<0.05). The expression of PI-PLCε1gene of colon cancer tissue was not effected by tumor differentiation and tumor site ( P>0.05). The results of immuno-histochemistry showed that the positive expression rate of PI-PLCε1 protein in colon cancer tissue was significantly lower than that in the adjacent tissue ( P<0.05). The positive expression rate of PI-PLCε1 protein was not effected by tumor differentiation ( P>0.05), but the expression was different in tumor site ( P<0.05). Conclusion Expression of PI-PLCε1 was reduced in colon tissue and barely to tumor differentiation.