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APG治疗糖尿病难治性皮肤溃疡对创面肉芽组织中MMP-1、MMP-9及TIMP-1水平的影响
Dynamic Changes of MMP-1, MMP-9 and TIMP-1 in the Refractory Diabetic Dermal Ulcers Treated by Autologous Platelet-rich Gel
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关键词:
- 自体富血小板凝胶 /
- 糖尿病 /
- 难治性皮肤溃疡 /
- 基质金属蛋白酶 /
- 基质金属蛋白酶抑制因子
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[9] Mohan R, Chintala SK, Jung JC, et al. Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration. J Biol Chem,2002;277(3):2065-2072.
[10] Wall SJ, Bevan D, Thomas DW, et al. Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse. J Invest Dermatol,2002;119(1):91-98.
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[14] Liu Y, Min D, Bolton T, et al. Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers. Diabetes Care,2009;32(1):117-119.
[15] Cox JH, Overall CM. Cytokine substrates:MMP regulation of inflammatory signaling molecules. In:Edwards D.The Cancer Degradome Proteases and Cancer Biology. New York:Springer,2008:519-539.
[16] Bullen EC, Longaker MT, Updike DL, et al. Tissue inhibitor of metalloproteinases-1 is decreased and activated gelatinases are increased in chronic wounds. J Invest Dermatol,1995;104(2):236-240.
[17] Vaalamo M, Weckroth M, Puolakkainen P, et al. Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds. Br J Dermatol,1996;135(1):52-59.
[18] Vaalamo M, Leivo T, Saarialho-Kere U. Differential expression of tissue inhibitors of metalloproteinases (TIMP-1, -2, -3, and -4) in normal and aberrant wound healing. Hum Pathol,1999;30(7):795-802.
[19] Varelias A, Cowin AJ, Adams D, et al. Mitogenic bovine whey extract modulates matrix metalloproteinase-2, -9, and tissue inhibitor of matrix metalloproteinase-2 levels in chronic leg ulcers. Wound Repair Regen,2006;14(1):28-37.
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