Abstract: The 21th century is the century of exploring and utilizing the underground space. In the future,more and more people will spend more and more time living or/and working in the underground space. However, we know little about the effect on the health of human caused by the underground environment. Herein, we systematically put forward the strategic conception of the deep-underground medicine, in order to reveal relative effects and mechanism of the potential factors in the deep underground space on human’s physiological and psychological healthy, and to work out the corresponding countermeasures. The original deep-underground medicine includes the following items. ①To model different depth of underground environment according to various parameters (such as temperature, radiation, air pressure,rock, microorganism)，and to explore their quantitative character and effects on human health and mechanism. ② To study the psychological change，maintenance of homeostasis and biothythm of organism in the deep underground space. ③ To learn the association between psychological healthy of human and the depth,structure,physical environment and working time of underground space. ④ To investigate the effect of different terrane and lithology on healthy of human and to deliberate their contribution on organism growth. ⑤ To research the character and their mechanism of growth, metabolism, exchange of energy, response of growth,aging and adaptation of cells living in deep underground space. ⑥ To explore the physiological feature, growth of microbiome and it’s interaction with host in the deep underground space. ⑦ To develop deep-underground simulation space，the biologically medical technology and equipments. As a research basis, a deep-underground medical lab under a rock thickness of about 1 470 m has been built, which aims to operate the research of the effect on living organism caused by different depth of underground environment.