Abstract: Objective To investigate the changes of blood lipid, fasting blood glucose and blood uric acid and its clinical significance in people with subclinical hypothyroidism. Methods Body mass index (BMI), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG) and uric acid (UA) were measured and compared in 356 people with subclinical hypothyroidism and 331 health people (controls). Results Compared to the control group, people with subclinical hypothyroidism had higher levels of BMI, TSH, TC, LDL-C，TG，FBG，UA (P<0.05) and non-significant decrease of HDL-C (P>0.05). The level of TSH was positively correlated with TC (r=0.254), LDL-C (r=0.110), TG （r=0.218）, BMI （r=0.119） and FBG （r=0.210） (P<0.05). The level of HDL-C was not correlated with TSH (P>0.05). Conclusion Thyroid dysfunction may have an effect on the metabolism of blood lipid, FBG and UA.