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肺癌诊治水平的进展与提高

Advances and Improvements in the Diagnoses and Treatments of Lung Cancer

  • 摘要: 目的 肺癌是恶性肿瘤死亡的首要原因。本专题主要针对肺癌流行病学、早期筛查及诊断、以及治疗策略等热点问题进行研究,提出目前肺癌的临床流行病学及病理类型分布的变化,阐述低剂量CT及孤立性结节影像学特点在肺癌早期筛查诊断中的价值,研究晚期脑转移肺癌及肺肉瘤样癌患者的治疗策略,并探索靶向治疗的新靶点。在规范化诊治的基础上,通过基础研究获得新发现并逐步应用于临床,从而提高肺癌高危人群早期筛查的准确率,从分子病理水平对肺癌进行分子分型,充分实现个体化治疗,改善晚期肺癌治疗策略,达到改善患者生存和预后的目的。

     

    Abstract: 【Abstract】 Objective To identify predictive factors associated with the improvement of social functioning of schizophrenia patients in a community. Methods 101 schizophrenia patients undergoing community rehabilitation were assessed with the Positive and Negative Syndrome Scale (PANSS), Personal and Social Performance Scale (PSP), Self-Esteem Scale (SES), Family Function Questionnaire (APGAR), and the World Health Organization Disability Assessment Scale Ⅱ (WHODAS-Ⅱ) twice 6 months apart. Pearson correlation and hierarchical multiple linear regression analyses were performed to identify the influencing and predictive factors associated with the improvement of social functioning. Results The increase of PSP score was correlated with age (r=0.220), reduced PANSS negative score (r=0.468), reduced PANSS general score (r=0.392), reduced PANSS total score (r=0.472), and reduced WHODAS-Ⅱ Score (r=0.247). The predictive factors of the change of PSP score followed the following order: change of PANSS negative score 〔the change of coefficient of determination (ΔR 2)=0.197〕, age of onset (ΔR 2=0.048), change of WHODAS-Ⅱ score and psychiatric rehabilitation (ΔR 2=0.031). Conclusion Improvement of negative symptoms predicts the short-term improvement of social functioning of schizophrenia patients.

     

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