口腔扁平苔藓病损区STAT1和IFN-γ的表达

何娟; 蔡扬

口腔扁平苔藓病损区STAT1和IFN-γ的表达

何娟,
蔡扬

The Over-expression of STAT1 and IFN-γ in Lesions of Human Oral Lichen Planus

HE Juan,
CAI Yang

摘要

摘要: 目的探讨信号转导与转录激活因子1（STAT1)、干扰素-γ(IFN-γ)在口腔扁平苔藓(OLP）病损发生发展中的作用。方法 48例OLP及10例正常口腔黏膜石蜡包埋组织，采用免疫组化SABC法检测相应组织中STAT1和IFN-γ蛋白的表达情况，分析其与OLP患者临床病理特征的相关性。结果 ①STAT1、IFN-γ 在OLP病损区表达阳性率均高于正常对照组，差异有统计学意义(Pχ2＝5.042，Pr=0.324, Pχ2=5.077，Pr=-0.388, P<0.05）。结论 OLP局部组织中存在STAT1和IFN-γ蛋白高表达，IFN-γ/STAT1通路在OLP局部病损形成过程中起到推动作用。

Abstract: Objective?To understand the possible role of signal transducer and activator of transcription 1 (STAT1) and interferon-γ (IFN-γ) in the generation of local lesions of oral lichen planus (OLP). Methods?Formalin-fixed, paraffin-embedded tissues of 10 cases of normal oral epithelium and 48 cases of OLP were investigated for STAT1 and IFN-γ proteins by using immunohistochemistry SABC method. The correlation between the expression of STAT1 and IFN-γ proteins and the clinical and pathological characteristics in OLP were statistically analyzed. Results ① STAT1 and IFN-γ were over expressed compared with healthy oral mucosa (Pχ2=5.042，?Pr=0.324, Pχ2=5.077, Pr=-0.388, P<0.05). Conclusion?The over-expression of STAT1 and IFN-γ may participate in the generation of local pathological damnification of OLP at the early stage.

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