Abstract: ObjectiveTo investigate the feasibility and effect of precise thoracoscopic lobectomy in children. Methods The clinical data of precise thoracoscopic lobectomy in infants and children were analyzed retrospectively in West China Hospital of Sichuan University. Results There were total 128 cases (male 69, female 59) of precise thoracoscopic lobectomy in infants and children from Oct, 2013 to March, 2017, which including 62 cases of congenital cyst of lungs, 47 cases of cystic adenomatoid malformations, 17 cases of pulmonary sequestrations, and 2 cases of lung tumors. The lesions cvere located in upper lobe of lung in 28 cases, lower lobe in 98 cases and middle lobe in 2 cases. Intraoperative pulmonary arteriovenous, bronchial and interlobar fissure tissues were precisely treated. One case was converted to open surgery because of the thoracic adhesions due to repeated infection, the remaining cases were successfully completed under the endoscopic procedure. Intraoperative bleeding was 3-5 mL, operation time was 35-120 min, mean 55 min. The closed thoracic drainage tubes were removed within 24 h postoperatively; No atelectasis, bleeding, bronchial pleural fistula, pulmonary infection and other complications occurred. The post-operative hospital day ranged 3-4 d. During the follow-up for 6-36 months, all cases were recovered well, and no recurrence occurred. Conclusion Meticulous thoracoscopic lobectomy is feasible in children, and it is effective in avoiding common postoperative complications, accelerating the recovery and shortening the hospitalization time.