Abstract: Objective To observe the clinical efficacy of Qingre Jiedu and Huoxue Huayu Recipe on the prednisone-dependant patients with chronic primary immune thrombocytopenic purpura (CPITP). Methods Fifty prednisone-dependant CPITP patients were treated with Qingre Jiedu and Huoxue Huayu Recipe orally one dose a day, the dosage of prednisone for these patients was tapered according to the monitoring result of blood platelet count (BPC).The therapeutic efficacy in these patients was evaluated before and after Chinese medicine treatment over 4 weeks. Results After the treatment of chinese medicine, BPC was increased from (28.6±22.5) ×10⁹ L^-1 to (81.8±56.5）×10⁹ L^-1 (P<0.05). The dosage of prednisone was decreased from (28.1±15.2) mg/d to (8.0±9.4) mg/d (P<0.05). Complement response, response and no response rate were 2%, 10% and 88% before Chinese medicine treatment, which were 30%,46% and 24% after Chinese medicine treatment, respectively (P＜0.05). Conclusion Qingre Jiedu and Huoxue Huayu Recipe could be effective in the treatment of prednisone-dependant patients with CPITP, and could decrease the dosage of prednisone.