Abstract: ObjectiveTo evaluate the outcomes of valve replacement of endocarditis using bioprothetic and mechanical valves. Methods This study comprised 52 patients 〔mean age （47±18) yr., mean follow-up time (6.2±3.8) years〕 underwent valve endocarditis with bioprotheses, The control group were matched (3∶1) with 156 patients of endocarditis underwent mechanical valves replacement using the following variables: age±5 yr., body mass index (BMI)±20%, time of operation±1 year, replacement position and sex ratio. And evaluate the effects of using bioprothetic and mechanical valves on perioperative and long-term outcomes of valve replacement of endocarditis. Results The perioperative mortality of the patients receiving bioprothetic and mechanical valves were 17.3%±2.2% and 19.9%±1.8%, respectively, which was independent of valve type (P=0.27). Long-term survival were 56.1%±5.2% and 61.2%±8.1%, respectively (P=0.58). Meanwhile, long-term complication-free survival were 75.0%±3.2% and 82.3%±4.4%, respectively (P=0.29). For the patients younger than or equal to 60 yr., long-term reoperation rates for bioprothetic and mechanical valves were 41.4%±7.2% and 30.5%±5.4% (P=0.02). For the patients older than 60 yr., however, reoperation rates were 24.1%±8.5% and 14.7%±5.7% (P=0.36). Conclusion Perioperative mortality and long-term survival are independent to valve types in patients with endocarditis. Mechanical valve shows potential advantage compared with bioprothetic valve in the patients younger than 60-year-old.