Abstract: 【Abstract】 Objective To explore the dermoscopic changes facial rejuvenation after the combination therapy of gold microacupuncture, Hyaluronic acid (HA) injection, and recombinant bovine alkaline fibroblast growth factor (rbbFGF). Methods Twenty cases of patients (age from 30 to 55 yearold) with facial skin naturally aging were included. The patients received multisource radio frequency therapeutic apparatus for injection at the subbermaldermal levels from 1316 W. Noncrosslinking HA of 2 mL was injected in the upper dermis. rbbFGF was externally applied 3 to 5 times a day for a week according to the dry skin issues, humanlike collagen mask was applied once a day for a week. Dermoscopy was used to observe the changes of skin, such as olor spot, wrinkle, skin texture and pore. Results The patients were found facial contour tighten, skin quality improved obviously after two phase combination therapy, the objective evaluation of dermoscopy delicated skin mirror, skin texture, skin moisture condition improved obviously, while the subjective satisfaction degree was increased. Conclusion Golden microacupuncture combined with HA injection and rbbFGF could provide better joint treatment for facial rejuvenation.