Abstract: Objectitve?To explore the mechanism of human umbilicmesenchymal cells (HUMSCs) implantation for the treatment of diabetic foot in rats associate with vascular endothelia growth factor (VEGF) expression changes. Methods?After diabetic foot model in rats were established by administration of streptozotozin (STZ) in intraperitoneal injection (2 weeks), ulceration in foot was induced by incision injury combined with swearing staphylococcus aureas. Then, HUMSCs were smeared on the ulceration of foot in diabetic rats. Ten days later, the densities of blood vessel and the level of VEGF expression were determined by using immunohistochemistry, RT-PCR and Western blot. Results?HUMSC grafts reduced significantly the volume of ulceration in diabetic foot rats (P<0.05). RT-PCR and Western blot showed that VEGF and its mRNA were significantly upregulated (P<0.05). VEGF immunstaining was found in blood vessels and the densities of blood vessels in HUMSC group were increased significantly (P<0.05). Conclusion?HUMSC implantation showed a positive role in promoting the recovery of the ulceration in foot with diabetic rats.