Abstract: Objective To investigate the clinical significances of plasma IL-6, CRP and TNF-α concentration changes in aortic dissection. Methods Plasma concentrations of IL-6, TNF-α and CRP were determined in 68 aortic dissection patients,50 patients with essential hypertensionand 50 healthy volunteers.The changes of plasma IL-6, CRP and TNF-α concentration were analyzed in aortic group along with the progression of the disease which was divided into 9 different time courses. Results Compared with essential hypertension and healthy control group,significantly elevated CRP,IL-6 and TNF-α concentrations were detected in aortic dissection patients (\P<0.05,respectively). All the concentrations of CRP,IL-6 and TNF-α reached the peak in acute phase of aortic dissection and then gradually declined in subacute and chronic phase.Conclusion Increased plasma inflammatory factors were significantly associated with aortic dissection.