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宫颈癌组织中c-myc、bcat1的表达及其临床意义
The Expression and Significance of c-myc and bcat1 in Cervical Cancer
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摘要: 目的 探究c-myc、bcat1表达与宫颈癌发生发展及临床特征的关系。方法 采用免疫组织化学方法半定量检测30例正常宫颈组织、30例宫颈上皮内瘤变（CIN）组织、80例宫颈癌组织（40例宫颈鳞癌、40例宫颈腺癌）中c-myc及bcat1蛋白的表达情况，并进行Spearman秩相关分析，分析两者表达水平与宫颈癌临床病理因素间的关系。结果 c-myc在正常宫颈组织、CIN组织、宫颈癌组织中的阳性表达率分别为16.7%（5/30）、43.3%(13/30)、73.8%(59/80)；bcat1阳性表达率分别为10.0%（3/30）、23.3%(7/30)、52.5%(42/80)；c-myc与bcat1在宫颈鳞癌及腺癌组织中的秩相关系数rs分别为0.773（P=0.000）、0.369(P=0.019);c-myc阳性表达率与癌组织病理类型（腺癌/鳞癌）、癌组织分化程度、间质浸润深度、有无脉管浸润有关(P<0.05)；bcat1阳性表达率与癌组织分化程度、有无脉管浸润及Ki67指数有关(P<0.05)。结论 c-myc的高表达可能促进宫颈癌的侵袭及转移，bcat1的高表达可能促进宫颈癌的增殖、侵袭与转移，两者可能在宫颈癌致病过程中存在协同作用。Abstract: Objective To explore the relationship between c-myc and bcat1 expression and the occurrence, development and clinical features of cervical cancer. Methods The expression level of c-myc and bcat1 were detected in 30 cases of normal cervical tissues, 30 cases of CIN tissues, 40 cases of cervical squamous carcinoma tissues and 40 cases of cervical adenocarcinoma tissues by immunohistochemistry; Conduct a Spearman rank correlation analysis between c-myc and bcat1 expressions; Analyze the relationship between the expression of both genes and clinicopathological factors of cervical cancer. Results The positive rates of c-myc expression were 16.7% (5/30) in normal cervical tissues, 43.3% (13/30) in CIN tissues and 73.8% (59/80) in cervical cancer tissues, the positive rates of bcat1 expression were 10.0% (3/30) in normal cervical tissues, 23.3% (7/30) in CIN tissues and 52.5% (42/80) in cervical cancer tissues. The rank correlation index between c-myc and bcat1 is respectively 0.773 (P=0.000) in cervical squamous carcinoma and 0.369 (P=0.019) in adenocarcinoma. The positive expression rate of c-myc was related to the pathological type of cancer tissue (adenocarcinoma/squamous cell carcinoma), the degree of tumor tissue differentiation, the depth of interstitial infiltration, and the presence or absence of vascular invasion (P<0.05). The positive expression rate of bcat1 was related to the degree of tumor differentiation, vascular invasion and Ki67 index (P<0.05). Conclusion The high expression of c-myc may promote the invasion and metastasis of cervical cancer, and the high expression of bcat1 may promote the proliferation, invasion and metastasis of cervical cancer, which may have a synergistic effect in the pathogenesis of cervical cancer.
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