Abstract: Objective To investigate the safety and efficay of low-dose furosemide in the correction of oliguria in the patients undergoing gynecologic surgery. Methods A total of 120 patients, aged between 20 to 50 years old, who were scheduled to receive elective gynecological open surgery under general anesthesia, were randomly divided into 3 groups:the control group, furosemide 0.05 mg/kg (F_0.5) group and furosemide 0.1 mg/kg (F₁) group (n=40). During surgery, blood volume and blood pressure was maintained in the normal range. The urine volume was recorded every 30 minutes. Oliguria was defined as the urine volume less than 0.5 mL/(kg·h), When oliguria was observed, flurosemide or saline was given to the patients based on the enrollment status. If the patients were still oliguric 30 min later, the treatment was repeated. The total time of surgery, net fluid infusion volume, urine volume per unit time per body weight at the completion of surgery, the incidence of intraoperative oliguria, the total amount of furosemide and the average specific gravity of urine were recorded. Results There was no statistically significant difference in sex, age, fasting time, the total time of surgery and intraoperative net fluid infusion volume among the three groups (P>0.05). The urine volume per unit time per body weight in control group was significantly lower than that of the other two groups (P<0.01). The incidence of intraoperative oliguria in the three groups (control, low dose, high dose groups) were 52.5%, 12.5% and 0%, respectively (P<0.01). Conclusion Low-dose of furosemide could maintain normal urine volume and specific gravity of urine during gynecological surgery.