Abstract: Objective To explore the therapeutic effects and advantages of dual channel and dual cycle regimen in the treatment of severe ovarian hyperstimulation syndrome (OHSS) with pregnancy. Methods This study enrolled 60 severe OHSS patients who were successfully pregnant with vitro fertilization-embryo transfer (IVF-ET). The patients were divided into conventional single cycle treatment group (Group A) and dual cycle and dual channel treatment group (Group B). Before the treatment and at the 3^rd d and 9^th d of treatment, all the patients received the measurements of body mass (BM), abdominal circumference (AC), maximum depth of ascites in ultrasonic (D), serum albumin (ALB), Na⁺ concentration, white blood cell count (WBC), hematocrit (HCT), drink intake (Intake) and urine volume. The hospital days and costs, the times of paracentesis, the amount of albumin used and pregnancy outcomes were compared at discharge day. Results At the 3^rd d of treatment, the changes of BM and HCT between the two groups had not significant difference, but AC and WBC were reduced in both groups, and Group B reduced more ( P<0.05). At the 9^th d of treatment，both groups had HCT，AC，D and WBC reduced as well as urine volume and Intake increased, Group B showed more changes ( P<0.05). Compared to the levels of ALB before treatment, it was lower at the 3^rd d but higher at the 9^th d in both group, with more changes found in Group B ( P<0.05). Compared with Group A, Group B had shorter hospital day, less use of album and paracentesis ( P<0.05). All patients in Group B were successful pregnant, one patient in Group A terminated pregnancy because of poor treatment effect. Conclusion Dual-circulation and dual-channel therapeutic regimen could improve hypoproteinemia, low osmotic pressure, low blood volume for OHSS patients.