Abstract: Pre-eclampsia is a serious obstetric complication, not only affect maternal health, but also affect the long-term prognosis of offspring generation. Even though various theories on the pathogenesis of pre-eclampsia have been proposed in recent decades, it remains unclear due to the disadvantages in these theories. Therefore, the pathogenesis of pre-eclampsia keeps attracting a lot of research efforts in the field of obstetrics. In order to find the new break through points in the study of pre-eclampsia pathogenesis (pre-eclampsia related to genetic, epigenetic and expression changes of some genes), it is necessary to illustrate and understand the research status in this field, with integrating the related resources, updating the new progress, ideas and extensive research means.