Abstract: Objective To study the relationship between hyperinsulinemia and primary periodic paralysis in overweight/obesity people. Methods Overweight/obesity people with primary hypokalemic periodic paralysis were administrated as disease group. Serum potassium, insulin and glucose were analyzed at different time (0 h, 1 h, 2 h, 3 h, 4 h) after taking 100 g carbohydrates and the results were compared with that of control group matched by gender, age and body mass index (BMI). Results ① Males were much more than females in disease group (14 males and 2 females), the onset age ranged from 20 to 50 years old. ②Both the highest insulin level and the lowest potassium level appeared at one hour after taking the carbohydrates. And the highest insulin level of disease group was significant higher than that of control group.③The area under the curve of insulin and insulin/potassium of disease group was significant higher than that of control group. Conclusion The postprandial hyperinsulinemia was an important factor in overweight/obesity people with hypokalemic periodic paralysis.