Abstract: Standardized clinical trial reporting is crucial for ensuring the scientific validity, reproducibility, and clinical translational value of reported results. The Consolidated Standards of Reporting Trials (CONSORT) statement, an internationally recognized guideline for randomized controlled trials (RCTs), has become an important reference standard for writing research papers in medicine since the 2010 version of CONSORT was published. With advancements in scientific research methodologies and the emergence of new forms of clinical trials, the CONSORT working group released an updated version in April 2025, published in journals such as The BMJ. Herein, we provide a systematic interpretation of the core revisions of CONSORT 2025, as well as a comparison with CONSORT 2010 to highlight the key differences. By providing practical, example-based recommendations, we aim to help domestic researchers apply the new guidelines efficiently, thereby improving the quality of clinical trial reports authored by domestic researchers.