Abstract: Totally implantable venous access ports (TIVAP) are widely applied in cancer patients, primarily those requiring long-term intravenous infusion. Given the absence of clinical practice guidelines designed specifically for the use of TIVAP in cancer patients, the National Cancer Center, the Professional Committee of Interventional Oncology of Chinese Anti-Cancer Association, the Professional Committee on Minimally Invasive Intervention of World Association of Chinese Oncology, the Professional Committee of Intervention of Beijing Association of Oncology, and cancer prevention and control institutions from various provinces and cities have jointly established a guideline compilation committee comprising multidisciplinary experts. Drawing upon the latest research findings, this guideline has been formulated. It comprehensively covers the clinical application indications, preoperative preparation, intraoperative procedures, postoperative care, usage and maintenance, removal techniques, complication management, and quality control indicators related to TIVAP use in cancer patients. The recommendations were graded using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to ensure that the TIVAP technology can be used to serve cancer patients with greater safety and efficiency in clinical practice, thereby enhancing overall medical quality and patient satisfaction.