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宫腔灌注粒细胞集落刺激因子改善薄型子宫内膜患者内膜及血流参数的前瞻性临床对照试验

Effect of Intrauterine Perfusion of Granulocyte Colony-Stimulating Factor on Endometrium and Blood Flow Parameters in Patients With Thin Endometrium: A Prospective Controlled Clinical Trial

    摘要
  • 摘要:
    目的  探究粒细胞集落刺激因子（granulocyte colony-stimulating factor, G-CSF）宫腔灌注对薄型子宫内膜患者内膜厚度、容积、血流参数及临床结局的影响。
    方法  本研究为前瞻性非随机同期对照试验，将2021年9月1日至2023年9月1日于绵阳市中心医院生殖中心行冻胚移植（frozen-thawed embryo transfer, FET）的薄型子宫内膜患者，分为实验组（行G-CSF宫腔灌注）和对照组（未行G-CSF宫腔灌注）。将两组患者的一般资料和临床结局进行统计分析，将实验组患者G-CSF灌注前后的内膜厚度、容积及血流参数进行统计分析。
    结果  共纳入83例患者，实验组51例，对照组32例，两组患者基线资料无明显差异。实验组患者临床妊娠率（56.86%）高于对照组（50.00%），自然流产率（27.59%）低于对照组（37.50%），但差异无统计学意义（P>0.05）。实验组患者G-CSF宫腔灌注后的内膜厚度〔（0.67±0.1） cm〕大于灌注前〔（0.59±0.09） cm〕，灌注后的子宫内膜容积〔（1.84±0.81） cm3〕大于灌注前〔（1.54±0.69） cm3〕，灌注后的VFI（1.97±2.82）大于灌注前（0.99±1.04），差异均有统计学意义（P<0.05）。
    结论  宫腔灌注G-CSF可改善薄型子宫内膜患者的内膜厚度、容积及部分血流参数。

     

    Abstract:
    Objective  To investigate the effects of intrauterine perfusion with granulocyte colony-stimulating factor (G-CSF) on the endometrial thickness, volume, and blood flow parameters of patients with thin endometrium and their clinical outcomes.
    Methods  We designed a prospective non-randomized synchronous controlled trial and recruited patients with thin endometrium who underwent frozen-thawed embryo transfer (FET) at Mianyang Central Hospital between September 1, 2021 and September 1, 2023. They were divided into two groups, an experimental group of patients who received the experimental treatment of intrauterine perfusion with G-CSF and a control group of patients who did not receive the experimental treatment. The general data and the clinical outcomes of the two groups were analyzed and compared. The endometrial thickness, volume and blood flow parameters of patients in the experimental group before and after intrauterine perfusion with G-CSF were analyzed.
    Results  The clinical data of 83 patients were included in the study. The experimental group included 51 cases, while the control group included 31 cases. There were no significant differences in the baseline data between the two groups. The clinical pregnancy rate of the experimental group (56.86%) was higher than that of the control group (50.00%) and the rate of spontaneous abortion in the experimental group (27.59%) was lower than that in the control group (37.50%), but the differences were not statistically significant (P>0.05). In the experimental group, the postperfusion endometrial thickness (0.67±0.1 cm) was greater than the preperfusion endometrial thickness (0.59±0.09 cm), the postperfusion (1.84±0.81 cm3) was greater than the preperfusion endometrial volume (1.54±0.69 cm3), and the postperfusion vascularization flow index (VFI) (1.97±2.82) was greater than the preperfusion VFI (0.99±1.04), with all the differences being statistically significant (P<0.05).
    Conclusion  Intrauterine perfusion with G-CSF can enhance the endometrial thickness, volume, and some blood flow parameters in patients with thin endometrium.

     

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