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基于logistic回归的关节置换术患者术后睡眠障碍风险预测模型构建研究

Postoperative Sleep Disturbance in Patients Undergoing Arthroplasty: Risk Prediction Modeling Based on Logistic Regression

  • 摘要:
      目的  使用logistic回归构建适合于关节置换术患者术后睡眠障碍(postoperative sleep disturbance, PSD)的风险预测模型。
      方法  回顾性收集四川省成都市某三甲医院2017年1月1日–2021年9月30日行关节置换术的4286例患者资料,其中3001例作为训练集,1285例作为测试集,在Matlab中使用逻辑回归算法筛选预测因子建模,采用列线图展示术后睡眠障碍预测风险。使用受试者工作特征曲线下面积(area under the curve, AUC)、准确率、精度、召回率、F1值和校准曲线进行模型效果评价。
      结果  本研究最终纳入入院后术前是否睡眠障碍、病房类型、体质量指数、是否吸烟、疾病范围、关节活动度(屈曲)、关节活动度(伸)、术前末次血红蛋白以及手术类型等9个预测因子进入模型构建。预测模型的AUC值为0.708(95%置信区间:0.677~0.740),准确率为75.20%,精度为65.80%,召回率为43.70%,F1值为0.525,校准曲线显示预测概率与实际一致性较好。
      结论  本研究构建的模型预测效能良好,且列线图简便易操作,医护人员可根据预测因子在关节置换术患者术前预测PSD的发生风险,便于及早进行预防,降低患者发生PSD的风险。

     

    Abstract:
      Objective  To construct a risk predictive model for postoperative sleep disturbance (PSD) in patients undergoing arthroplasty by using logistic regression.
      Methods  We retrospectively collected the data of 4286 patients who underwent joint replacement surgeries at a tertiary-care hospital in Chengdu, China between January 1, 2017 and September 30, 2021. With 3001 cases in the training set and 1285 cases in the test set, we constructed the model by using a logistic regression algorithm to screen for predictors in Matlab, displaying the predicted risks of postoperative sleep disturbance with nomographs. The performance of the model was assessed by the area under the curve (AUC) of the receiver operating characteristic curve, accuracy, precision, recall, F1 value, and calibration curve.
      Results   A total of 9 predictors, including post-admission preoperative sleep disturbance, ward type, body mass index, smoking status, range of diseases, joint mobility (flexion), joint mobility (extension), preoperative last hemoglobin, and type of surgery, were eventually included in the study for predictive modeling . The performance assessment findings of the predictive model were as follows, AUC value, 0.708 (95% confidence interval: 0.677-0.740), accuracy, 75.20%, precision, 65.80%, recall, 43.70%, and F1 value, 0.525. The calibration curve showed good agreement between the predicted probabilities and the actual data.
      Conclusion  The model constructed in the study has good predictive efficacy and the nomographs are simple and easy to use. With this model, health workers can make preoperative prediction of the risk of PSD in arthroplasty patients based on the predictors, which facilitates early prevention and reduces the risk of postoperative sleep disturbance in patients.

     

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