基于罗马Ⅳ标准的中国高校学生功能性消化不良和肠易激综合征现况调查

高旭; 刘娜; 郝宇杰; 张晓辉; 杨倩; 蒋潇洒; 刘奕辛; 蔡雅琴; 宋萍; 纪泛扑; 王进海

doi:10.12182/20230560208

基于罗马Ⅳ标准的中国高校学生功能性消化不良和肠易激综合征现况调查

Prevalence Survey of Functional Dyspepsia and Irritable Bowel Syndrome in Chinese College Students Based on Rome Ⅳ Diagnostic Criteria

摘要

摘要:
目的了解我国高校学生功能性消化不良（functional dyspepsia, FD）、肠易激综合征（irritable bowel syndrome, IBS）的患病率及危险因素。
方法本研究采用网络电子问卷为主联合现场调查为辅的调查方法，对17～35岁之间的中国各地高校学生进行在线问卷调查, 最终纳入2025份有效问卷进行统计分析。统计学方法采用χ²检验和logistic回归。
结果符合罗马Ⅳ标准高校学生FD患病率为5.5%（112/2025），以餐后不适综合征（postprandial distress syndrome, PDS）（66.1%，74/112）为主，吸烟〔比值比（OR）=2.334，95%置信区间（CI）：1.187～4.589, P=0.014〕、抑郁（OR=2.447，95%CI：1.421～4.214, P=0.001）、失眠（OR=1.947，95%CI：1.291～2.937, P=0.001）与FD患病呈正相关。IBS患病率为1.9%（38/2025），以腹泻型（diarrhea-predominant IBS, IBS-D）为主（44.7%），焦虑（OR=3.63，95%CI：1.34～9.88，P=0.012）、失眠（OR=2.35，95%CI：1.18～4.68, P=0.015）与IBS患病呈正相关。
结论基于罗马Ⅳ标准，IBS、FD在中国高校学生中患病并不少见，心理障碍和一些相关的生活方式因素可能与疾病发展有关，未来应该在中国开展更多基于不同诊断标准、不同地域、多因素的系列研究。

Abstract:
Objective To investigate the prevalence and risk factors of functional dyspepsia (FD) and irritable bowel syndrome (IBS) among college students in China.
Methods An online questionnaire survey of college students aged 17-35 from across China was conducted. The online questionnaire survey was supplemented by an offline survey. A total of 2025 valid samples were included for statistical analysis. χ² test and logistic regression were performed for statistical analysis.
Results The prevalence of FD among college students who met the Rome Ⅳ diagnostic criteria was 5.5% (112/2025), with most of them, or 66.1% (74/112), suffering from postprandial discomfort syndrome (PDS). Smoking (odds ratio OR=2.334, 95% confidence interval CI: 1.187-4.589, P=0.014), depression (OR=2.447, 95% CI: 1.421-4.214, P=0.001), and insomnia (OR=1.947, 95% CI: 1.291-2.937, P=0.001) were positively correlated with the prevalence of FD. The prevalence of IBS was 1.9% (38/2025), with IBS-diarrhea dominant (IBS-D) being the most important subtype that accounted for 44.7%. Anxiety (OR=3.63, 95% CI: 1.34-9.88, P=0.012) and insomnia (OR=2.35, 95% CI: 1.18-4.68, P=0.015) were positively correlated with the prevalence of IBS.
Conclusion Based on Rome Ⅳ criteria, IBS and FD are not uncommon among Chinese university students. Psychological disorders and some related lifestyle factors may be related to the development of the disease. In the future, more series of studies based on different diagnostic criteria, different regions, and multiple factors should be conducted in China.

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