牙龈卟啉单胞菌与非口腔疾病关系的研究进展

Developments in Research on the Relationship Between Porphyromonas gingivalis and Non-Oral Diseases

摘要: 牙龈卟啉单胞菌是常见的牙周致病菌。近来，大量证据表明牙龈卟啉单胞菌不仅是口腔中常见致病菌，而且与非口腔疾病密切相关，包括炎症性肠炎、癌症、心血管疾病、阿尔茨海默病、类风湿关节炎、糖尿病、早产及非酒精性肝炎等。本文就近年来关于牙周致病菌牙龈卟啉单胞菌与非口腔疾病关系的研究进展进行综述，有助于判别牙龈卟啉单胞菌是否可作为这些非口腔疾病的辅助诊断标记和潜在治疗靶标，进而有利于开发相关疾病的治疗策略。

Abstract: Porphyromonas gingivalis (P. gingivalis) is a common periodontal pathogen. Recently, there has been increasing evidence suggesting that P. gingivalis is not only a common pathogen in the oral cavity, but is also closely associated with non-oral diseases, including inflammatory bowel disease, cancer, cardiovascular diseases, Alzheimer's disease, rheumatoid arthritis, diabetes mellitus, premature birth and non-alcoholic hepatitis, etc. Herein, we reviewed the developments in recent years in research on the relationship between P. gingivalis, a periodontal pathogen, and non-oral diseases, which will help determine whether P. gingivalis could be used as an auxiliary diagnostic biomarker or a potential therapeutic target for these non-oral diseases, thus contributing to the development of treatment strategies for the relevant diseases.