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代东跃, 李博磊, 李明云, 等. 微生物与巨噬细胞相互调控并介导口腔癌发生发展的研究进展[J]. 四川大学学报(医学版), 2023, 54(1): 27-32. DOI: 10.12182/20230160205
引用本文: 代东跃, 李博磊, 李明云, 等. 微生物与巨噬细胞相互调控并介导口腔癌发生发展的研究进展[J]. 四川大学学报(医学版), 2023, 54(1): 27-32. DOI: 10.12182/20230160205
DAI Dong-yue, LI Bo-lei, LI Ming-yun, et al. Research Progress on the Interaction Between Microorganisms and Macrophages and Their Role in the Mediation of the Onset and Development of Oral Cancer[J]. Journal of Sichuan University (Medical Sciences), 2023, 54(1): 27-32. DOI: 10.12182/20230160205
Citation: DAI Dong-yue, LI Bo-lei, LI Ming-yun, et al. Research Progress on the Interaction Between Microorganisms and Macrophages and Their Role in the Mediation of the Onset and Development of Oral Cancer[J]. Journal of Sichuan University (Medical Sciences), 2023, 54(1): 27-32. DOI: 10.12182/20230160205

微生物与巨噬细胞相互调控并介导口腔癌发生发展的研究进展

Research Progress on the Interaction Between Microorganisms and Macrophages and Their Role in the Mediation of the Onset and Development of Oral Cancer

  • 摘要: 口腔鳞状细胞癌是世界第六大常见的恶性肿瘤,目前临床治疗效果并不理想。由于其所在部位的特殊性,口腔癌与多种微生物关系密切,且其发生发展极易受到微生物的调控。免疫系统的介导作用在肿瘤发生发展过程中也不可或缺,尤其是肿瘤相关巨噬细胞,其具有放大微生物调控作用的能力,并反过来调控微生物种群组分及数量,相辅相成,共同加剧口腔癌的恶化。本文旨在总结目前微生物和巨噬细胞之间的相互关系,以及微生物、巨噬细胞对口腔癌发生发展的调控作用等相关工作,并对于微生物、巨噬细胞以及口腔癌之间的深层次关系的研究现状与不足进行讨论。微生物和巨噬细胞都被认为是有前景的预后指标,有望成为新的治疗靶点。尽管目前已有学者关注着微生物及巨噬细胞在口腔癌中的作用,但少有研究将其与口腔癌前病变联系起来,微生物与巨噬细胞间相互调控关系也仍不明晰。因此,对于微生物、巨噬细胞、口腔癌三者关系网络的深度探索有望为肿瘤的早期诊断及治疗提供更多的可能性。

     

    Abstract: Oral squamous cell carcinoma is the sixth most common malignant tumor in the world, and the clinical treatment effect is not satisfactory. Because of the special nature of its location, oral cancer is inextricably linked with a wide variety of microorganisms, and its pathogenesis and development are also extremely susceptible to microbial regulation. In addition, the mediating role of the immune system is also indispensable to the course of tumor pathogenesis and development, especially tumor-associated macrophages, which amplify the regulatory role of microorganisms, and in turn regulate the microbial population components--two complementary effects that jointly exacerbate oral cancer. Herein, we summarized the existing research on the relationship between microorganisms and macrophages, as well as the regulatory role of microorganisms and macrophages in the pathogenesis and development of oral cancer. We also discussed the current status of and gaps in research on the relationship between microorganisms and macrophages and oral cancer. Both microorganisms and macrophages are considered promising indicators for prognosis, showing potentials to be used as new therapeutic targets. Despite some research interest in the role of microorganisms and macrophages in oral cancer, very few studies have linked them to oral precancerous lesions, and the mutual regulatory relationship between microorganisms and macrophages remains unclear. Therefore, in-depth exploration of the relationship network of microorganisms, macrophages and oral cancer is expected to provide more possibilities for the early diagnosis and treatment of tumors.

     

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