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雷紫雪, 林永旺, 李雨庆, 等. 烟酰胺在口腔及全身疾病防治中的研究进展[J]. 四川大学学报(医学版), 2023, 54(1): 14-19. DOI: 10.12182/20230160105
引用本文: 雷紫雪, 林永旺, 李雨庆, 等. 烟酰胺在口腔及全身疾病防治中的研究进展[J]. 四川大学学报(医学版), 2023, 54(1): 14-19. DOI: 10.12182/20230160105
LEI Zi-xue, LIN Yong-wang, LI Yu-qing, et al. Research Progress in Niacinamide in the Prevention and Treatment of Mouth and Systemic Diseases[J]. Journal of Sichuan University (Medical Sciences), 2023, 54(1): 14-19. DOI: 10.12182/20230160105
Citation: LEI Zi-xue, LIN Yong-wang, LI Yu-qing, et al. Research Progress in Niacinamide in the Prevention and Treatment of Mouth and Systemic Diseases[J]. Journal of Sichuan University (Medical Sciences), 2023, 54(1): 14-19. DOI: 10.12182/20230160105

烟酰胺在口腔及全身疾病防治中的研究进展

Research Progress in Niacinamide in the Prevention and Treatment of Mouth and Systemic Diseases

  • 摘要: 烟酰胺是烟酸的酰胺形式,也是烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide, NAD+)的前体之一,可以作为膳食补充剂或临床治疗药物,用于补充体内的NAD+水平,参与机体细胞代谢、DNA修复等关键功能。烟酰胺成本低廉、来源广泛、生物安全性好,还具有抗菌、抗炎、调节细胞免疫等多重生物功能,对皮肤疾病、神经变性疾病等具有明显的改善作用。然而,目前大部分有关烟酰胺的研究仍停留在实验室阶段,本文将对烟酰胺在口腔及全身疾病预防和治疗中的作用和机制进行综述,探究烟酰胺作为临床治疗药物的潜能,为烟酰胺在不同疾病防治中的临床应用提供一定的依据和参考,并对其未来的研究和应用前景进行展望。

     

    Abstract: Nicotinamide (NAM) is the amide form of niacin and one of the precursors of nicotinamide adenine dinucleotide (NAD+). NAM can be used as a dietary supplement or clinical therapeutic drug to replenish NAD+ levels in the human body and participate in key bodily functions such as cellular metabolism and DNA repair. NAM has the advantage of low cost, wide availability, and sound biosafety. It also has multiple biological functions, including antibacterial effect, anti-inflammatory effect, and modulation of cellular immunity, producing significant ameliorative effects on skin and neurodegenerative diseases. However, most studies on NAM are still at the laboratory stage. Herein we reviewed the role and mechanism of NAM in the prevention and treatment of oral and systemic diseases, explored its potential as clinical therapeutic medication, provided some basis and references for the clinical application of nicotinamide in the prevention and treatment of various diseases, and discussed its prospects for future research and application.

     

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