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陈国勇, 李真林. DWI和肝胆特异性对比剂Gd-EOB-DTPA在肝局灶性病变诊断和鉴别诊断中的应用现状[J]. 四川大学学报(医学版), 2022, 53(5): 737-743. DOI: 10.12182/20220960205
引用本文: 陈国勇, 李真林. DWI和肝胆特异性对比剂Gd-EOB-DTPA在肝局灶性病变诊断和鉴别诊断中的应用现状[J]. 四川大学学报(医学版), 2022, 53(5): 737-743. DOI: 10.12182/20220960205
CHEN Guo-yong, LI Zhen-lin. Application of Diffusion-Weighted Imaging and Hepatobiliary-Specific Contrast Agent Gd-EOB-DTPA in the Diagnosis and Differential Diagnosis of Focal Liver Lesions[J]. Journal of Sichuan University (Medical Sciences), 2022, 53(5): 737-743. DOI: 10.12182/20220960205
Citation: CHEN Guo-yong, LI Zhen-lin. Application of Diffusion-Weighted Imaging and Hepatobiliary-Specific Contrast Agent Gd-EOB-DTPA in the Diagnosis and Differential Diagnosis of Focal Liver Lesions[J]. Journal of Sichuan University (Medical Sciences), 2022, 53(5): 737-743. DOI: 10.12182/20220960205

DWI和肝胆特异性对比剂Gd-EOB-DTPA在肝局灶性病变诊断和鉴别诊断中的应用现状

Application of Diffusion-Weighted Imaging and Hepatobiliary-Specific Contrast Agent Gd-EOB-DTPA in the Diagnosis and Differential Diagnosis of Focal Liver Lesions

  • 摘要: 肝脏局灶性病变(FLL)种类繁多,征象各异,其诊断和鉴别诊断相对困难。尽早对FLL进行准确检出、分类和定性具有重要临床意义。扩散加权成像(DWI)可提供肝脏细胞密度、微观结构和微循环灌注方面的信息,肝胆特异性对比剂钆塞酸二钠(Gd-EOB-DTPA)增强肝脏磁共振成像(MRI)检查可提供病变的血流灌注信息和正常肝细胞摄取功能的特异性信息,二者联合应用可显著提高肝局灶性病变检出的敏感性和诊断准确性。本文对现阶段国内外有关DWI和Gd-EOB-DTPA在FLL中的应用研究进行综述,以期为临床应用提供参考。现有研究大多数只是比较和探讨了Gd-EOB-DTPA增强前后不同b值的DWI图像质量及其拟合表观弥散系数(ADC)值,所得结果多种多样、并不统一,Gd-EOB-DTPA是否会对DWI图像产生影响仍然存在一定争议。未来的研究应对注射Gd-EOB-DTPA后的增强效应,以及增强前后不同b值对应的自身ADC值的变化进行定量对比、讨论和验证,以期为临床应用提供更加客观和统一的研究结果。

     

    Abstract: There are many types of focal liver lesions (FLL) presenting different lesion signs and their diagnosis and differential diagnosis are relatively difficult. It is of great clinical significance to accurately detect, classify and characterize focal liver lesions as soon as possible. Diffusion-weighted imaging (DWI) provides information on liver cell density, microstructure, and microcirculation perfusion. Gadolinium-ethoxibenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is a hepatobiliary-specific contrast agent. Gd-EOB-DTPA-enhanced MRI examination of liver provides information on the blood perfusion of lesions and specific information on the uptake function of normal liver cells. The combined application of the two can significantly improve the sensitivity and diagnostic accuracy in the detection of FLL. Herein, we reviewed the research findings on the application of DWI and Gd-EOB-DTPA in FLL diagnosis in order to provide reference for further clinical application. Most of the existing studies only made comparison and discussion of the DWI image quality of different b values and their fitted apparent diffusion coefficient (ADC) values before and after Gd-EOB-DTPA enhancement, and the reported findings are not only varied, but also inconsistent. Whether Gd-EOB-DTPA will affect DWI images is still been debated. Future research should focus on quantitative comparison, discussion and verification of the enhancement effect after injection of Gd-EOB-DTPA, as well as the changes in the ADC value corresponding to different b values before and after enhancement, in order to provide more objective and consistent research results for clinical application.

     

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