Abstract: Objective To investigate hepatitis C virus (HCV) genotype distribution detected in West China Hospital of Sichuan University. Methods We analyzed genotype distribution data on HCV infected patients who had information of HCV genotypes from January 2009 to December 2013 diagnosed in West China Hospital of Sichuan University. Results Five genotypes and 15 genetic subtypes of HCV were found among the 1 998 cases, and 4 of the patients were infected with mixed HCV subtype. Among those genotypes and genetic subtypes, genotype 1a was detected in 8 cases (0.40%), genotype 1b in 1 368 cases (68.47%), genotype 1c in 18 cases (0.90%), genotype 2a in 78 cases (3.90%), genotype 2b in 1 case (0.05%), genotype 2i in 16 cases (0.80%), genotype 3a in 291 cases (14.56%), genotype 3b in 154 cases (7.71%), genotype 3k in 4 cases (0.20%), genotype 5a in 1 case (0.05%), genotype 6a in 50 cases (2.50%), genotype 6b in 3 cases (0.15%), genotype 6h in 1 case (0.05%), genotype 6n in 1 case (0.05%), mixed-genotype 1b/1c in 1 case (0.05%), mixed-genotype 1b/6h in 1 case (0.05%), mixed-genotype 2c/2a in 1 case (0.05%), and mixed-genotype 3b/3k in 1 case (0.05%). The distribution of five main HCV genetic subtypes on gender had no statistical significance (P ＞0.05), and its distribution on people with different ages had statistical significance (P <0.05). Conclusion The major genotypes of HCV were 1b (predominant), 3a, 3b, 2a, 6a in patients diagnosed in West China Hospital of Sichuan University, with the existence of single-genotype 1a, 1c, 2b, 2i, 3k, 5a, 6b, 6h, 6n and mixed-genotype 1b/1c, 1b/6h, 2c/2a, 3b/3k, indicating the diversity of HCV genotype.