自发性2型糖尿病恒河猴双心室形变的心脏磁共振分析

朱桐; 曾文; 陈榆舒; 张钰; 孙家瑜; 程巍; 王磊; 龚立; 郜发宝

自发性2型糖尿病恒河猴双心室形变的心脏磁共振分析

Cardiac Magnetic Resonance Imaging Study of Ventricular Myocardial Deformation in Spontaneous T2DM Rhesus Monkey

摘要

摘要:
目的利用心脏磁共振组织追踪技术(CMR-tissue tracking)探讨自发性2型糖尿病(T2DM)恒河猴双心室的心肌形变特征。
方法选取12只雄性自发性T2DM恒河猴以及9只年龄、性别及体质量匹配的健康恒河猴，排除高血压、心肌梗死；测定空腹血糖、糖化血红蛋白水平以及血脂水平；行CMR扫描覆盖左、右心室的电影序列，使用常规心功能分析及CMR-tissue tracking后处理评价双心室的心功能以及心肌形变。
结果 T2DM组空腹血糖及糖化血红蛋白水平明显增高，两组间体质量、年龄差异无统计学意义。心功能分析显示T2DM组双心室射血分数均无显著降低；组织追踪结果显示右室自由壁的收缩形变参数〔包括径向及环向应变峰值(Err、Ecc)、收缩期应变率峰值(SSRR、SSRC)的大小〕均明显降低，舒张形变参数〔包括径向、环向和纵向舒张期应变率峰值(DSRR、DSRC、DSRL)的大小〕均显著降低；而左室的收缩形变参数〔径向及环向应变峰值(Err、Ecc)〕以及舒张形变参数〔径向舒张期应变率峰值(DSRR)〕显著降低。
结论 CMR-tissue tracking技术能发现自发性T2DM恒河猴的右心室与左心室同时存在收缩及舒张形变功能的异常。

Abstract:
Objective To assess biventricular, especially right ventricular, function and deformationin rhesus monkeys with spontaneous type 2 diabetes mellitus (T2DM) using cardiac magnetic resonance (CMR).
Methods Twelve male spontaneous T2DM rhesus monkeys and age, sex, body mass matched 9 healthy rhesus monkeys without hypertension and myocardial infarction were included in this study. Fasting blood glucose (FPG), glycated hemoglobin (HbA1c) and blood liquid levels were measured. Biventricular function and myocardial deformations were evaluated by CMR cine and tissue-tracking.
Results Compared with control, the FPG and HbA1c levers were significantly increased in T2DM group, but there was no significant difference in body mass and age between the two groups. CMR result showed that there was no significant decrease in right ventricle and left ventricle ejection fraction in T2DM (P < 0.05). However, the absolute value of radial and circumferential global peak systolic strain, systolic strain rate and three directions global peak diastolic strain rate of the right ventricle free wall were lower in the T2DM group (P < 0.05). Also, only radial and circumferential peak systolic strain and radial diastolic strain rate of left ventricle were higher (P < 0.05).
Conclusion Right ventricle showed systolic and diastolic dysfunction which were consistent with left ventricle in T2DM by CMR-tissue tracking.

HTML全文

参考文献(18)

施引文献

资源附件(0)

开放获取 本文遵循知识共享署名—非商业性使用4.0国际许可协议（CC BY-NC 4.0），允许第三方对本刊发表的论文自由共享（即在任何媒介以任何形式复制、发行原文）、演绎（即修改、转换或以原文为基础进行创作），必须给出适当的署名，提供指向本文许可协议的链接，同时标明是否对原文作了修改；不得将本文用于商业目的。CC BY-NC 4.0许可协议详情请访问 https://creativecommons.org/licenses/by-nc/4.0