Abstract: Objective To investigate the change of leptin, adiponectin and visfatin levels in adult growth hormone deficiency (GHD) patients, and its relationship with other indicators. Methods 40 adult GHD patients (19 males) entered the observation group with 36 cases of healthy individuals (18 males) as the control group. Basic information (height, body mass, waistline, hipline etc.) was collected from both groups. Fasting venous blood samples were collected to measure the leptin, adiponectin and visfatin levels. Results The GHD group had a higher waist to hip ratio, and higher levels of cholesterol, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), leptin, adiponectin and visfatin, but lower levels of growth hormone (GH), insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and dehydroepiandrosterone sulfate (DHEA-S) when campared with that of the control group (P<0.05). Logistic regression analysis demonstrated that adult GHD patients are associated with elevated levels of visfatin (OR=1.430, P<0.05). Conclusion Our study implied that adult GHD patients are associated with elevated levels of visfatin.