血浆IL-6、CRP和TNF-α水平在主动脉夹层患者病程中的变化及意义

钟明华; 古君; 张尔永

血浆IL-6、CRP和TNF-α水平在主动脉夹层患者病程中的变化及意义

Clinical Significances of Plasma Interleukin-6,C-reaction Protein and Tumor Necrosis Factor-α in Patients with Aortic Dissection

摘要

摘要: 目的通过检测主动脉夹层患者血浆中白细胞介素（IL）-6、肿瘤坏死因子-α（TNF-α）和C-反应蛋白（CRP）3种炎症介质的浓度，探讨其在病程中的变化及临床意义。方法分别使用ELISA法检测68例主动脉夹层患者、50例单纯原发性高血压患者及50例健康成人血浆中的IL-6、CRP、TNF-α浓度，将主动脉夹层组按照病程不同分为包含急性期到慢性期的9个时间段组别进行统计，分析夹层组炎症介质与另两组的差异及其随时间的变化趋势。结果主动脉夹层患者血浆中IL-6、CRP、TNF-α浓度均比正常人组、单纯原发性高血压组高（\P<0.05），3种炎症因子浓度峰值均出现于主动脉夹层病程急性期内，在亚急性期、慢性期逐渐降低。结论主动脉夹层患者血浆中IL-6、CRP和TNF-α在病程中扮演重要角色，炎症因子可作为评估主动脉夹层患者全身炎症反应的强度、辅助诊断及评估早期预后的指标。

Abstract: Objective To investigate the clinical significances of plasma IL-6, CRP and TNF-α concentration changes in aortic dissection. Methods Plasma concentrations of IL-6, TNF-α and CRP were determined in 68 aortic dissection patients,50 patients with essential hypertensionand 50 healthy volunteers.The changes of plasma IL-6, CRP and TNF-α concentration were analyzed in aortic group along with the progression of the disease which was divided into 9 different time courses. Results Compared with essential hypertension and healthy control group,significantly elevated CRP,IL-6 and TNF-α concentrations were detected in aortic dissection patients (\P<0.05,respectively). All the concentrations of CRP,IL-6 and TNF-α reached the peak in acute phase of aortic dissection and then gradually declined in subacute and chronic phase.Conclusion Increased plasma inflammatory factors were significantly associated with aortic dissection.

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