CD147、OPN和MMP-2在口腔鳞状细胞癌中的表达及意义

张弛; 满大鹏; 马术明; 曹树文; 李东文

CD147、OPN和MMP-2在口腔鳞状细胞癌中的表达及意义

Expressions and Significances of CD147,OPN and MMP-2 in Oral Squamous Cell Carcinoma

摘要

摘要: 目的研究口腔鳞状细胞癌（OSCC）中基质金属蛋白酶诱导因子（CD147）、骨桥蛋白（OPN）和基质金属蛋白酶-2（MMP-2）的表达和意义。方法采用免疫组化SP法对35例OSCC组织中CD147、OPN和MMP-2的表达进行检测，并分析这3个指标间的相关性。结果 CD147、OPN和MMP-2在OSCC组织中高表达，阳性表达率分别为65.71%、71.43%、68.57%；三者的表达均与OSCC病理分级、临床分期和淋巴结转移有关（P<0.05），而与性别、年龄、生长部位无明显相关性（P>0.05）；随着病理分级的降低、临床分期的增高和淋巴结转移，三者的阳性表达率均升高；三者之间的表达互呈正相关（MMP-2和CD147，r=0.653；MMP-2和OPN，r=0.540；CD147和OPN，r=0.381；P均<0.05）。结论 CD147、OPN和MMP-2的表达与OSCC的病理分级及侵袭转移密切相关。

Abstract: Objective To evaluate the expressions and significances of CD147,OPN and MMP-2 in oral squamous cell carcinoma(OSCC). Methods The expressions of CD147,OPN and MMP-2 were detected by immunohistochemical method (SP) in 35 cases of OSCC. The relationships between the expressions of CD147,OPN and MMP-2 and clinic histopathologic parameters of OSCC were analyzed. Results The expression rates of CD147, OPN and MMP-2 in OSCC tissues were 65.71%,71.43% and 68.57% respectively. The expressions of CD147, OPN and MMP-2 were positively correlated with tumor histopathologic type, clinical stage and lymph node metastasis (P<0.05), but not correlated with age,gender and the location of tumor (P>0.05). The positive correlations were found among the expressions of CD147,OPN and MMP-2 (MMP-2 and CD147,r=0.653;MMP-2 and OPN,r=0.540;CD147 and OPN,r=0.381;P<0.05). Conclusion The expressions of CD147,OPN and MMP-2 increase in OSCC and may be the potential predictor of the malignant degree of OSCC.

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