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刘皓, 胡颖. 细胞衰老与肿瘤治疗[J]. 四川大学学报(医学版), 2021, 52(2): 176-181. DOI: 10.12182/20210360503
引用本文: 刘皓, 胡颖. 细胞衰老与肿瘤治疗[J]. 四川大学学报(医学版), 2021, 52(2): 176-181. DOI: 10.12182/20210360503
LIU Hao, HU Ying. A Review of Celluar Senescence and Tumor Treatment[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(2): 176-181. DOI: 10.12182/20210360503
Citation: LIU Hao, HU Ying. A Review of Celluar Senescence and Tumor Treatment[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(2): 176-181. DOI: 10.12182/20210360503

细胞衰老与肿瘤治疗

A Review of Celluar Senescence and Tumor Treatment

  • 摘要: 细胞衰老是细胞永久性周期阻滞,伴有多种分泌表型的发生。除促进细胞凋亡外,诱导细胞衰老是放化疗以及某些靶向药物抑制肿瘤的重要作用机制,然而细胞衰老作为细胞的自我保护性机制,在肿瘤治疗中的作用有利有弊。如何利用细胞衰老的抑瘤效应,并有效避免其可能产生的促瘤效应,提高肿瘤治疗的敏感性,防止肿瘤的复发和转移,是细胞衰老研究的重要瓶颈问题。本文旨在综述细胞衰老在肿瘤治疗中的“双刃剑”效应,对衰老细胞通过其自主性与非自主性机制影响肿瘤治疗效果的具体机制进行归纳和讨论,为提高肿瘤治疗效果提供指导,推动细胞衰老在肿瘤治疗的基础与临床应用研究。

     

    Abstract: Cellular senescence is a permanent state of cell cycle arrest, combined with the acquisition of a variety of secretory phenotypes. In addition to apoptosis, the induction of cellular senescence is an important mechanism that chemo- and radiotherapies and some targeted therapies rely on to produce an anti-tumor effect. However, being a self-protective mechanism of cells, cellular senescence can produce both positive and negative effects in tumor treatment. It remains a challenge to effectively utilize the anti-tumor effect of cellular senescence while averting the pro-tumor effect. How to improve the sensitivity of tumor treatment and to prevent tumor recurrence and metastasis has become the bottleneck in cellular senescence research. We summarize in this review the “double-edged-sword” effect of cellular senescence in tumor treatment. We summarize and discuss the cell autonomous and non-autonomous mechanisms that senescent cells use to affect tumor treatment, hoping to provide information that will help improve the outcome of tumor treatment and promote further research in basic and clinical application of cellular senescence in tumor treatment.

     

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