Effect of Ingested Immunoglobulin on SIgA Expression in Pediatric Rotavirus Enteritis

Objective To identify the effects of ingested anti-rotavirus immunoglobulin on enteric expressions of SIgA in pediatric rotavirus enteritis. Methods In this randomized, placebo controlled clinic trial, 100 patients of pediatric rotavirus enteritis who simultaneously received fluid replacement as basic therapy, were randomly divided into control and immunoglobulin treated groups. The patients in experimental group were given “ingested anti-rotavirus IgY”. Stool sample was collected at day 1, 3, 5, 7, 9 and 11, the level of fecal SIgA was quantifies by radioimmunoassay kit, and fecal rotavirus shedding was detected by double-sandwich ELISA. Results The frequency of diarrhea in immunoglobulin group was obviously less than that in control group (P <0.05). The mean course of diarrhea was (4.5±0.92) d in immunoglobulin group, and (5.8±1.68) d in control group (P =0.015). The fecal SIgA level in immunoglobulin group was higher than that in control group(P <0.05). The doubling time of SIgA level was the 3 ^rd d in immunoglobulin group, and the 5^th d in control group. The fecal rotavirus shedding in immunoglobulin group was obviously lower than that in control group (P <0.05). Conclusion Ingested anti-rotavirus immunoglobulin could promote the expression of enteric SIgA to remove rotavirus, achieving the benefit to release diarrhea in pediatric rotavirus enteritis.