Effects of Early Enteral Immunonutrition on Postoperative Immune Function and Rehabilitation of

Objective To investigate the effects of early enteral immunonutrition on postoperative immune function and rehabilitation of gastric cancer patients with nutritional risk. Methods New hospitalized patients with gastric cancer were evaluated the nutrient status based on NRS 2002. The patients who scored between 3 to 5 points were randomized into two groups(30 cases for each group), and those in experimental group were given 7-d early postoperative enteral immune nutrition,those in control group were given normal nutrition. The immune indexes (CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺) and nutritional indexes(transferrin, pre-albumin, albumin) were measured before operation and at the 3^rd and 7^th day postoperatively. In addition, the first flatus time, gastrointestinal adverse reactions and complications, length of hospital stays were compared between the two groups. Results The level of CD4⁺/CD8⁺ and transferrin, pre-albumin, albumin in experimental group were significantly higher than those in control group at the third and seventh day postoperatively (P<0.05).Compared with the control group, the experimental group had shorter first flatus time after surgery, which were （63.5±7.3） h vs. （72.8±8.6 ） h respectively (P<0.05).There were no statistically difference on pneumonia, anastomosis leakage, severe abdominal distension, inflammatory bowel obstruction and total postoperative hospitalization time between the two groups (P>0.05).Conclusion Early enteral immunonutrition can effectively promote the recovery of nutritional status and immune function in gastric cancer patients with nutrition risk.