Effects of Huoxue Dingxuan Capsule Glare on Vertebral Artery Blood Flow, Plasma PAI and t-PA in CSA Rat Models

Objective To determine the effects of Huoxue Dingxuan Capsule on vertebral artery blood flow, plasma plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in rats with cervical spondylosis of vertebral artery type (CSA). Methods Ninety healthy male Wistar rats were equally and randomly divided into control, model and treatment groups. The rats in the model and treatment groups were subject to composite modeling manufacturing CSA. The treatment group was given six-week interventions with Huoxue Dingxuan capsule 4 weeks after the modeling. Vertebral artery blood flow, plasma PAI, and t-PA contents were detected before modeling, prior to the interventions, and post interventions. Results Before the interventions, the rats in the model and treatment groups had significantly lower blood flow of vertebral artery than the controls (P<0.05). The model rats also had increased serum PAI and t-PA contents (P<0.01). After the interventions, significantly higher vertebral blood flow was found in the treatment group compared with the controls (P<0.05). After the interventions, increased serum PAI and t-PA contents were observed in the rats in the model group (P<0.01); whereas, decreased serum PAI and t-PA contents were observed in the rats in the treatment group (P<0.01). The treatment group had lower levels of serum PAI and t-PA contents than the model group (P<0.01). Conclusion Huoxue Dingxuan Capsule glare can improve the blood flow of vertebral artery and reduce serum PAI and t-PA contents.