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Volume 50 Issue 5
Sep.  2019
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ZHU Tong, ZENG Wen, CHEN Yu-shu, et al. Cardiac Magnetic Resonance Imaging Study of Ventricular Myocardial Deformation in Spontaneous T2DM Rhesus Monkey[J]. Journal of Sichuan University (Medical Sciences), 2019, 50(5): 695-700.
Citation: ZHU Tong, ZENG Wen, CHEN Yu-shu, et al. Cardiac Magnetic Resonance Imaging Study of Ventricular Myocardial Deformation in Spontaneous T2DM Rhesus Monkey[J]. Journal of Sichuan University (Medical Sciences), 2019, 50(5): 695-700.
shu

Cardiac Magnetic Resonance Imaging Study of Ventricular Myocardial Deformation in Spontaneous T2DM Rhesus Monkey

  • 1.

    Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China

  • 2.

    Sichuan Primed Shines Bio-tech Co., Ltd, Chengdu 610041, China

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  • Corresponding author:

    GAO Fa-bao, E-mail: gaofabao@yahoo.com

  • Received Date: January 28, 2019
  • Revised Date: May 15, 2019
  • Available Online: March 16, 2021
  • Published Date: September 19, 2019
    Abstract
  •   Objective   To assess biventricular, especially right ventricular, function and deformationin rhesus monkeys with spontaneous type 2 diabetes mellitus (T2DM) using cardiac magnetic resonance (CMR).
      Methods   Twelve male spontaneous T2DM rhesus monkeys and age, sex, body mass matched 9 healthy rhesus monkeys without hypertension and myocardial infarction were included in this study. Fasting blood glucose (FPG), glycated hemoglobin (HbA1c) and blood liquid levels were measured. Biventricular function and myocardial deformations were evaluated by CMR cine and tissue-tracking.
      Results   Compared with control, the FPG and HbA1c levers were significantly increased in T2DM group, but there was no significant difference in body mass and age between the two groups. CMR result showed that there was no significant decrease in right ventricle and left ventricle ejection fraction in T2DM (P < 0.05). However, the absolute value of radial and circumferential global peak systolic strain, systolic strain rate and three directions global peak diastolic strain rate of the right ventricle free wall were lower in the T2DM group (P < 0.05). Also, only radial and circumferential peak systolic strain and radial diastolic strain rate of left ventricle were higher (P < 0.05).
      Conclusion   Right ventricle showed systolic and diastolic dysfunction which were consistent with left ventricle in T2DM by CMR-tissue tracking.
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    • References (18)
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