Study of Glycated Albumin Cut-off Point in Diabetes Mellitus and Impaired Glucose Regulation

【Abstract】 Objective To investigate the cut-off point of glycated albumin (GA) in the detection of diabetes mellitus (DM) and impaired glucose regulation (IGR). Methods This study was conducted in 20-84 years-old adults who had risk factors of diabetes but no previously diagnosed diabetes. There were finally 392 individuals included and received the measurement of GA and HbA1c. Receiver operating characteristic curve (ROC) was plotted to determine the performance of GA. Results ①Based on the diabetes diagnosis criteria of WHO (1999), the subjects were divided into DM group (n=131), IGR group (n126), and normal glucose tolerance (NGT) group (n=135). The GA level in the three groups tended to increase (Pr=0.942 1, Pr=0.856 6, P r=0.813 7, P AUC) =0.888〕， producing the sensitivity of 71.8% and the specificity of 87.4%. Conclusion GA as a single screening test shows adequate to detect newly diagnosed DM, and the optimal GA cut-off point was 16.6% in this study.