Effects of “Reinforcing Qi and Activating Blood” on Stable Chronic Obstructive Pulmonary Disease (Qi Deficiency and Blood Stasis Syndrome)

Objective To study the clinical effects of "Reinforcing Qi and Activating Blood" in the treatment of stable chronic obstructive pulmonary disease (Qi Deficiency and Blood Stasis Syndrome). Methods This study recruit 50 outpatients with stabe chronic obstructive pulmonary disease (Qi Deficiency and Blood Stasis Syndrome), who were randomly divided into 2 groups, control group and treatment of "Reinforcing Qi and Activating Blood" group. The patients in control group were given conventional treatment, while the patients in treatment group not only received conventional treatment but also the treatment of Yu-Ping-Feng capsules and Fu-Fang-Dan-Shen tablets for 3 months. The duration of follow up was 12 months, and chinese medicine (CM) symptoms, cellular immunity indexes and haemodynamics indexes were assessed every 3 months. Results The total effective rate in treatment group at 3 months treatment and 3 months follow-up were higher than that in control group(P<0.05). The CM symptoms in treatment group were improved significantly (P<0.05). In treatment group, the level of CD4 and the ratio of CD4/CD8 after therapy were higher than those before (P<0.05), and the level of CD8 was lower than that before (P<0.05). The level of NO was no significant difference (P>0.05), while the level of endothelin (ET) was significantly different (P<0.05). The frequency of suffering from cold, the admission due to acute exacerbation and hospital stay in treatment group were all lower than those in control group(P<0.05). Conclusion The "Reinforcing Qi and Activating Blood" therapy can improve the symptoms and clinical curative effect of TCM in the treatment of stable COPD (Qi Deficiency and Blood Stasis Syndrome), with the improvement of their cellular immunological function and vasomotor function.