Expression and Clinical Significances of c-myb and Bax Proteins in Endometrial Carcinoma

Objective To study the expressions of c-myb and Bax proteins and their relationships with clinic-pathological characteristics in endometrial carcinoma. Methods The expressions of c-myb and Bax protein were detected by immunohistochemistry in 42 normal endometrial tissues and 68 endometrial carcinoma tissues. Apoptosis index was detected by TUNEL technique. Results The positive expression rates of c-myb and Bax in endometrial carcinoma were significantly higher than those in normal endometrial tissues (P<0.05). The expressions of c-myb and Bax in low differentiated endometrial carcinoma were higher than those in high and middle differentiated endometrial carcinoma (P<0.05). The expressions of c-myb and Bax in stage Ⅲ and stage Ⅳ endometrial carcinoma were higher than those in stageⅠand stgeⅡ endometrial carcinoma (P<0.05). Apoptosis index in endometrial carcinoma was higher than that in normal endometrial carcinoma.The poorer the cellular differentiation was, the higher the apoptosis index was. There was positive correlation between the expression of Bax and apoptosis index (P<0.05), but no correlation between the expression of c-myb and apoptosis index (P>0.05). Conclusion Endometrial carcinoma has high expression of c-myb and Bax, and the expression status of both c-myb and Bax may be related to the malignant degree and prognosis of endometrial carcinoma.