A Retrospective Analysis of Clinical Features of Interstitial Pneumonia with Autoimmune Features

Objective To analyze the clinical features of interstitial pneumonia with autoimmune features （IPAF） and the correlation between them. MethodsWe respectively analyzed the patients with interstitial lung disease （ILD） admitted in our hospital from January 2014 to January 2017. The patients who met all priori requirements and at least one feature of one domain were recuited,and the clinical features and autoimmune diseases related prognosis were analyzed. ResultsThere were 90 patients recruited, including 38 patients completely met IPAF classification criteria and 52 patients who incompletely met. The average age was (62.34±14.98) yr.. The pneumonia pattern of complete IPAF patients was non-specific interstitial pneumonia (NSIP), while it was usually interstitial pneumonia (UIP) in the incomplete IPAF patients. During follow-up, 11 patients were diagnosed with autoimmune diseases （4 with complete IPAF, and 7 with incomplete IPAF）. According to Cox regression analysis, completely meet the criteria of IPAF was related to the relapse of disease. ConclusionsThere exist relation between IPAF and autoimmune diseases. The patients with IPAFmay finally develop into autoimmune diseases. The IPAF classification criteria provide basic structure for this disease, but the limitation of the criteria call for revising by more clinical trials.