Effect of Dermal Multipotent Cells Transplantation on Skin Elasticity in Aged Murine

Objective To investigate the elasticity changes in aged dermis after injection of dermal multipotent cells (DMCs). Methods Dermal multipotent cells were isolated and cultured from 3-day-old BALB/c mice and then transplanted into the dermis of aged (12-week-old) BALB/c mice. Adult fibroblasts（FBs） were employed as control. At 2 and 4 weeks after the transplantation, we examined dermal elasticity by MPA580 skin test machine. Results The skin elasticity were improve at 2 weeks after the transplantion in both DMCs group and FBs group ( P= 0.000) but have no statistical difference between these two groups ( P=0.216). The different effect between these two groups appeared in 4 weeks after the transplantation ( P=0.031）. Conclusion Dermal multipotent cells appear more effective than fibroblasts in increasing skin elasticity.