Expressions and Significances of CD147,OPN and MMP-2 in Oral Squamous Cell Carcinoma

Objective To evaluate the expressions and significances of CD147,OPN and MMP-2 in oral squamous cell carcinoma(OSCC). Methods The expressions of CD147,OPN and MMP-2 were detected by immunohistochemical method (SP) in 35 cases of OSCC. The relationships between the expressions of CD147,OPN and MMP-2 and clinic histopathologic parameters of OSCC were analyzed. Results The expression rates of CD147, OPN and MMP-2 in OSCC tissues were 65.71%,71.43% and 68.57% respectively. The expressions of CD147, OPN and MMP-2 were positively correlated with tumor histopathologic type, clinical stage and lymph node metastasis (P<0.05), but not correlated with age,gender and the location of tumor (P>0.05). The positive correlations were found among the expressions of CD147,OPN and MMP-2 (MMP-2 and CD147,r=0.653;MMP-2 and OPN,r=0.540;CD147 and OPN,r=0.381;P<0.05). Conclusion The expressions of CD147,OPN and MMP-2 increase in OSCC and may be the potential predictor of the malignant degree of OSCC.