Relationship of Toll Like Receptors Expression and HPV16 Infection in Cervical Squamous Cell Cancer

WANG Tao; QIE Ming-rong

Volume 49 Issue 4

Jul. 2018

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JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCES) > 2018 > 49(4): 649-651,672.

WANG Tao, QIE Ming-rong. Relationship of Toll Like Receptors Expression and HPV16 Infection in Cervical Squamous Cell Cancer[J]. Journal of Sichuan University (Medical Sciences), 2018, 49(4): 649-651,672.

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Relationship of Toll Like Receptors Expression and HPV16 Infection in Cervical Squamous Cell Cancer

WANG Tao¹,
QIE Ming-rong^2, ,

1. Laboratory of Molecular Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China;
2. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China

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Received Date: January 14, 2018
Revised Date: May 29, 2018
Published Date: July 19, 2018

Abstract

Abstract

Objective To analyze the relationship between Toll like receptors (TLRs) mRNA expression levels and HPV16 infection in cervical squamous cell cancer (SCC). Methods Expression levels of TLRs mRNA and HPV16 in tissue samples collected from cervical squamous carcinoma and cervicitis were detected, and the relationship of TLRs mRNA expression and HPV infection was analyzed in two different disease groups. Results Expressions of TLRs mRNA were not related to HPV16 infection in cervical squamous cell cancer. Expression of TLR3 mRNA in cervical SCC was significantly lower than those of cervicitis. Expression of TLR5 mRNA was shown significant difference between moderately differentiated and poorly differentiated cervical SCC (P<0.05). Conclusion Expressions of TLRs mRNA were not related to HPV16 infection in cervical SCC. TLR3 may play a role in the pathogenesis in cervical SCC.
- TLRs,
- HPV16,
- Cervical squamous cell cancer,
- RT-PCR

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Relationship of Toll Like Receptors Expression and HPV16 Infection in Cervical Squamous Cell Cancer

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