Characteristics and Clinical Significance of Outer Retinal Tubulation in Wet Age-macular Degeneration Treated by

Objective To determine the characteristics and clinical significance of outer retinal tabulation (ORT) in wet age-related macular degeneration (wAMD) treated by anti-vascular endothelial growth factor （anti-VEGF） through optical coherence tomography (OCT). Methods The 35 wAMD patients with 39 ORT eyes treated by anti-VEGF were examined by OCT to determine the morphological features and evolution of the ORTs over time and their response to anti-VEGF. Results ORTs were located in the places that exudation or edema had happened in the outer nuclear layer of retina. 38 ORTs remained stable on both quantity and morphology. One ORT became invisible temporarily and then reappeared. Conclusion ORTs are reconstructed by photoreceptor cells that have survived after outer retina damages. There is no connection between anti-VEGF treatment and ORT formation.